Anticonvulsant activity of some xanthone derivatives was written by Marona, Henryk;Pekala, Elzbieta;Antkiewicz-Michaluk, Lucyna;Walczak, Maria;Szneler, Edward. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Formula: C5H13NO This article mentions the following:
A series of appropriate alkanolamine and amide derivatives of xanthone were prepared and evaluated for anticonvulsant activity using maximal electroshock (MES) and s.c. pentylenetetrazole (scMet) induced seizures, and for neurotoxicity (TOX) using the rotorod test on mice and rats. The most promising compounds seem to be the appropriate aminoalkanolic derivatives of 6-chloroxanthone, among which the R-(-) and S-(+)-2-amino-1-propanol derivatives of 6-chloro-2-methylxanthone (2a and 2b) displayed anti-MES activity (in mice) with a protective index (TD50/ED50) of 6.23<6.85, corresponding to that of phenytoin, carbamazepine and valproate. The most active compound, 2b, was determined to have an affinity to the benzodiazepine (BDZ) receptor and voltage-dependent Ca2+ channel (VDCC) by using radioligand binding assays. The enantiomeric purities of 2a and 2b were determined using an anal. liquid chromatog.-mass spectrometry method. In the experiment, the researchers used many compounds, for example, 3-Amino-3-methylbutan-1-ol (cas: 42514-50-1Formula: C5H13NO).
3-Amino-3-methylbutan-1-ol (cas: 42514-50-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C5H13NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts