Synthesis of Lafutidine was written by Tao, Feng;Lu, Chunxu. And the article was included in Zhongguo Yiyao Gongye Zazhi in 2004.Synthetic Route of C6H6BrNO This article mentions the following:
Lafutidine, a histamine H2-receptor antagonist, was synthesized by bromination, oxidation, reduction, oxidation, etherification of 2-amino-4-methylpyridine to give 2-[4-(tetrapyran-2-yloxyl)-(2Z)-buten-oxy]-4-(1,3-dioxolan-2-yl)pyridine, which was subjected to hydrolysis, chlorination, Gabriel reaction, hydrazinolysis in one pot followed by amidation, hydrolysis and then condensation with piperidine. The overall yield of lafutidine was 6.8%. In the experiment, the researchers used many compounds, for example, 2-Bromopyridine-4-methanol (cas: 118289-16-0Synthetic Route of C6H6BrNO).
2-Bromopyridine-4-methanol (cas: 118289-16-0) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C6H6BrNO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts