Yu, Qishun et al. published their research in Organometallics in 2021 | CAS: 120121-01-9

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of (R)-1-(3-Chlorophenyl)ethanol

Enantioselective Hydroboration of Ketones Catalyzed by Rare-Earth-Metal Complexes Supported with Phenoxy-Functionalized TsDPEN Ligands was written by Yu, Qishun;Lu, Chengrong;Zhao, Bei. And the article was included in Organometallics in 2021.Application In Synthesis of (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:

Six novel chiral rare-earth-metal complexes bearing the phenoxy-functionalized TsDPEN ligands I (H3Ln, R1, R2 = = tBu, Me, H, 1-adamantyl, OMe; R3 = 4-Me, 3-Me, 2-Me, 4-tBu, H, 4-F, 4-CF3) were prepared and well characterized. The solid-state structures of four tetranuclear rare-earth-metal complexes [Ln2L13]2 (1–4; R1 = R2 = tBu, R3 = 4-Me; Ln = Nd, Sm, Eu, Gd) and the dual-core yttrium complex [Y2L13] (5) were determined by X-ray diffraction, resp. The structure of lanthanum complex 6 was speculated by the 1H DOSY spectroscopy in THF-d8 together with DFT calculations Complexes 1–5 were employed to catalyze the enantioselective hydroboration of ketones and α,β-unsaturated ketones using pinacolborane (HBpin) as a reductant, and complex 1 gave better outcomes in comparison to the others. The corresponding secondary alcs. were obtained in excellent yields and moderate ee values. The same results were also achieved using the combined catalyst system of the neodymium amide Nd[N(SiMe3)2]3 with the phenoxy-functionalized TsDPEN ligand H3L1 in a 1:1.5 molar ratio. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Application In Synthesis of (R)-1-(3-Chlorophenyl)ethanol).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of (R)-1-(3-Chlorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts