New syntheses of 3-amino-1-propanol derivatives. I. Synthesis of 2-methyl-3-amino-1-propanol and 2-methyl-3-dimethylamino-1-propanol was written by Marcinkiewicz, Stefan. And the article was included in Acta Poloniae Pharmaceutica in 1971.SDS of cas: 14123-48-9 This article mentions the following:
CH2:C(Me)CN and 2 moles Me2NH kept 4 days in MeOH gave 91% Me2NCH2CH(Me)CN (I). I, hydrogenated 40 min at 80°/25 atm over Raney Ni, yielded 76% Me2NCH2CH(Me)CH2NH2, which, treated at 80° with HNO2 gave a mixture of Me2NCH2CH(Me)CH2OH (II) and Me2NCH2CMe2OH, whose separation by distillation failed. Me2C:NOH and 1.3 moles CH2:C(Me)CN, heated 4 hr in the presence of MeONa, yielded 50% Me2C:NOCH2CH(Me)CN (III). MeEtC.NOCH2CHMeCN was prepared analogously in 44% yield. III, hydrogenated at 60°/25 atm in MeOH-NH3 over Raney Ni, gave 94% HOCH2CH(Me)CH2NH2, which, refluxed with CH2O-HCO2H, yielded 85% II. II was also prepared in 65% yield by refluxing Me2NCH2CH(Me)CO2Me with Na in PhMe and EtOH. In the experiment, the researchers used many compounds, for example, 1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9SDS of cas: 14123-48-9).
1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 14123-48-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts