Photocatalytic Chemodivergent Synthesis of α-gem-Dihalovinyl Ketones and Chromen-2-Ones from Monoalkynes was written by Xu, Zi-Yang;Liu, Yin-Ping;Liu, Xin;Fu, Rong;Hao, Wen-Juan;Tu, Shu-Jiang;Jiang, Bo. And the article was included in Advanced Synthesis & Catalysis in 2022.Product Details of 2216-51-5 This article mentions the following:
A general photocatalytic substrate-controlled chemodivergent strategy starting from monoalkynes with polyhalomethanes such as BrCCl3 and CBr4 was developed, enabling Kharasch-type addition/nucleophilic substitution cascade to selectively produce α-gem-dihalovinyl ketones and chromen-2-ones with moderate to good yields. Use of monoalkynes without addnl. nucleophilic sites furnished α-gem-dihalovinyl ketones through a Kharasch-type addition and intermol. allylic substitution cascade whereas the latter transformation of 2-ethynylphenols allowed the full breaking of carbon-halogen bonds of BrCX3 to access functionalized chromen-2-ones. The late-stage application of these resulting α-gem-dihalovinyl ketones demonstrates the versatility of their derivatization. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Product Details of 2216-51-5).
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 2216-51-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts