Radical cascade synthesis of azoles via tandem hydrogen atom transfer was written by Chen, Andrew D.;Herbort, James H.;Wappes, Ethan A.;Nakafuku, Kohki M.;Mustafa, Darsheed N.;Nagib, David A.. And the article was included in Chemical Science.Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:
A radical cascade strategy for the modular synthesis of five-membered heteroarenes (e.g. oxazoles, imidazoles) I (R1 = Ph, 4-MeOC6H4, 4-F3C6H4, 2-naphthyl, biphenyl-4-yl, etc.; R2 = Ph, 2-pyridinyl, 4-IC6H4, 3-MeC6H4, etc.), II (R3 = 4-F3CC6H4, CCl3) from feedstock reagents (e.g. alcs., (R2CH2CH2OH), amines (such as., benzylamine, morpholine, pyrrolidine), nitriles R1CN) has been developed. This double C-H oxidation is enabled by in situ generated imidate R1C(=N)OCH2CH2R2 and acyloxy radicals, which afford regio- and chemo-selective β C-H bis-functionalization. The broad synthetic utility of this tandem hydrogen atom transfer (HAT) approach to access azoles is included, along with experiments and computations that provide insight into the selectivity and mechanism of both HAT events. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol).
2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts