A photocleavable stabilizer for the preparation of PHEMA nanogels by dispersion polymerization in supercritical carbon dioxide was written by Alaimo, David;Grignard, Bruno;Kuppan, Chandrasekar;Adriaensen, Yasmine;Genet, Michel J.;Dupont-Gillain, Christine;Gohy, Jean-Francois;Fustin, Charles-Andre;Detrembleur, Christophe;Jerome, Christine. And the article was included in Polymer Chemistry in 2017.Quality Control of 3-(Hydroxymethyl)-4-nitrophenol This article mentions the following:
A new photo-sensitive diblock copolymer composed of a hydrophilic sequence of poly(ethylene oxide) (PEO) linked to a CO2-philic sequence of poly(1H,1H,2H,2H-heptadecafluorodecyl acrylate) (PFDA) by a light sensitive o-nitrobenzyl group was successfully synthesized by RAFT polymerization and used as a stabilizer for the free radical polymerization of 2-hydroxyethyl methacrylate (HEMA) dispersion in α,α,α-trifluorotoluene and supercritical carbon dioxide (scCO2). Thanks to this fluorinated stabilizer, well-defined particles of PHEMA down to 350 nm diameter were produced in scCO2. Advantageously, the photocleavable group at the block junction of the stabilizer could be cleaved by exposing the particles to UV light so that the fluorinated block could be extracted in TFT or scCO2. As supported by XPS anal., up to 80% of the fluorinated block of the stabilizer can be removed, leading to efficient swelling and dispersion of the resulting PHEMA nanogels in water. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Quality Control of 3-(Hydroxymethyl)-4-nitrophenol).
3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of 3-(Hydroxymethyl)-4-nitrophenol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts