A new chiral sulfinyl-NH-pyridine ligand for Ir-catalyzed asymmetric transfer hydrogenation reaction was written by Tang, Lei;Wang, Qiwei;Wang, Juanjuan;Lin, Zechao;Wang, Xiaobei;Cun, Linfeng;Yuan, Weicheng;Zhu, Jin;Liao, Jian;Deng, Jingen. And the article was included in Tetrahedron Letters in 2012.Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:
A new flexible C1-sym. tridentate ligand (S)-N-(2-(tert-butylsulfinyl)benzyl)-1-(pyridin-2-yl)methanamine (I) was successfully prepared and utilized as a chiral ligand for Ir(I)-catalyzed ATH (asym. transfer hydrogenation) reactions. Without any cooperation of other chiral centers, encouraging ee and conversion values have been achieved, which provides a better understanding of these types of ligands and a new strategy to develop new high-efficiency chiral catalysts for asym. reactions. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol).
(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts