Complete chiral induction from enantiopure 1,2-diamines to benzophenone-based achiral bisphosphane ligands in Noyori-type RuII catalysts was written by Jing, Qing;Sandoval, Christian A.;Wang, Zheng;Ding, Kuiling. And the article was included in European Journal of Organic Chemistry in 2006.Related Products of 171032-87-4 This article mentions the following:
The design and synthesis are reported of a novel class of RuII catalysts (R,R)-I+Cl– (Ar = Ph, R = H, 5-t-Bu, 4-t-Bu; Ar = 3,5-Me2C6H3, R = H) composed of achiral benzophenone-based bisphosphine ligands and enantiopure 1,2-diamines for the asym. hydrogenation of aryl ketones. The developed catalysts show excellent enantioselectivities (up to 97% ee) and activities (up to S/C = 10,000) in the hydrogenation of a variety of aromatic ketones. Complete chiral induction from the enantiopure 1,2-diamine to the achiral bisphosphine ligand was observed The coordination of the C:O moiety in I to the cationic RuII center is considered to be of key importance in providing a higher thermodn. and kinetic rotation barrier for the flexible bisphosphine ligand, resulting in the preferential formation of only one diastereomer, and thus explaining the high enantioselectivity of the catalyst. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Related Products of 171032-87-4).
(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 171032-87-4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts