High activity iridium catalyst for the asymmetric hydrogenation of aromatic ketones was written by Li, Chun;Zhang, Lin;Du, You;Zheng, Xue-Li;Fu, Hai-Yan;Chen, Hua;Li, Rui-Xiang. And the article was included in Catalysis Communications in 2012.Application of 171032-87-4 This article mentions the following:
The asym. hydrogenation of aromatic ketones catalyzed by iridium complexes was investigated in the presence of chiral diamines and achiral phosphines. The catalytic system with triphenylphosphine and 9-amino(9-deoxy)epicinchonine exhibited high activity and enantioselectivity in the asym. hydrogenation of simple aromatic ketones. A series of simple aromatic ketones were hydrogenated completely in just 2 h at room temperature with good ee value (up to 87%). In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Application of 171032-87-4).
(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 171032-87-4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts