A QSAR study of Overton’s tadpole data was written by Lipnick, Robert L.. And the article was included in Progress in Clinical and Biological Research in 1989.Computed Properties of C10H22O3 This article mentions the following:
Previously published data (Overton, E., 1901) on the narcotic and toxic effects of a number of organic compounds in Rana temporaria tadpoles were evaluated for structure-activity relationships. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Computed Properties of C10H22O3).
rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Computed Properties of C10H22O3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts