Reifenrath, William G. published the artcilePercutaneous Absorption of an Insect Repellent p-Menthane-3,8-DIOL: A Model for Human Dermal Absorption, Recommanded Product: 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is menthanediol insect repellent skin absorption swine model solvent.
P-Menthane-3,8-diol(38DIOL) was recently introduced as a natural topical insect repellent in the com. product “”OFF! Botanicals”” lotion. The objective of this study was to provide an estimate of the potential for 38DIOL systemic absorption in humans. 14C 38DIOL formulated in the lotion and in an EtOH solution was applied to excised swine skin in an in vitro flow-through test system predictive of skin absorption in humans. Twenty-four hours after application, radiolabel recovered from the dermis and receptor fluid was summed to determine % absorption. At a dose of approx. 80 μg/cm2 of 38DIOL in the lotion, a value of 3.5 ± 0.8% of applied dose was obtained with swine skin. The corresponding value for 38DIOL in EtOH (90 μg/cm2) was not significantly different (3.0 ± 1.2%). Most of the applied dose of 38DIOL was found to evaporate from swine skin (77 ± 8% for the lotion and 87 ± 1% for EtOH solution), thus limiting percutaneous absorption values. For reference purposes, the swine skin absorptions of piperonyl butoxide (PBO) at 100 μg/cm2 in isopropanol, N,N-diethyl-m-toluamide (DEET) at 500 μg/cm2 in EtOH, and neat isododecane at 650 μg/cm2 (in order of increasing volatility) were 15 ± 6%, 23 ± 3%, and 0.09 ± 0.05% of applied dose resp. Isododecane was lost almost exclusively from the skin surface by evaporation For addnl. reference, absorptions of PBO, DEET, and 38DIOL were found to be higher with excised rat skin.
Journal of Toxicology and Environmental Health, Part A: Current Issues published new progress about Bioaccumulation. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Recommanded Product: 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.
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