Westphal, Matthias V. published the artcileWater-compatible cycloadditions of oligonucleotide-conjugated strained allenes for DNA-encoded library synthesis, COA of Formula: C10H9NO, the publication is Journal of the American Chemical Society (2020), 142(17), 7776-7782, database is CAplus and MEDLINE.
DNA-encoded libraries of small mols. are being explored extensively for the identification of binders in early drug-discovery efforts. Combinatorial syntheses of such libraries require water- and DNA-compatible reactions, and the paucity of these reactions currently limit the chem. features of resulting barcoded products. The present work introduces strain-promoted cycloadditions of cyclic allenes under mild conditions to DNA-encoded library synthesis. Owing to distinct cycloaddition modes of these reactive intermediates with activated olefins, 1,3-dipoles, and dienes, the process generates diverse mol. architectures from a single precursor. The resulting DNA-barcoded compounds exhibit unprecedented ring and topog. features, related to elements found to be powerful in phenotypic screening. DNA-encoded libraries of small mols. are being explored extensively for the identification of binders in early drug-discovery efforts. Combinatorial syntheses of such libraries require water- and DNA-compatible reactions, and the paucity of these reactions currently limit the chem. features of resulting barcoded products. The present work introduces strain-promoted cycloadditions of cyclic allenes under mild conditions to DNA-encoded library synthesis. Owing to distinct cycloaddition modes of these reactive intermediates with activated olefins, 1,3-dipoles and dienes, the process generates diverse mol. architectures from a single precursor. The resulting DNA-barcoded compounds exhibit unprecedented ring and topog. features-related to elements found to be powerful in phenotypic screening.
Journal of the American Chemical Society published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C15H21BO2, COA of Formula: C10H9NO.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts