Gou, Bo-Bo published the artcileScandium Triflate Catalyzed Tandem Transfer Hydrogenation and Cyclization Reaction of o-Aminobenzaldehydes and o-Aminoacetophenone with Alcohols, COA of Formula: C5H12O, the main research area is benzoxazine preparation; aminobenzaldehyde alc tandem hydrogenation cyclization reaction scandium triflate catalyst; alc aminoacetophenone tandem hydrogenation cyclization reaction scandium triflate catalyst.
An effective Sc-catalyzed transfer hydrogenation and cyclization tandem reaction has been achieved. This process showed excellent functional group compatibility and good yields. A variety of benzoxazines I (R = H, Me; R1 = H, Me, Et; R2 = Me, Ph, naphthalen-1-yl, thiophen-2-ylmethyl, etc.; R1R2 = -(CH2)5-; R3 = H, F, Cl, Me, Br; R4 = H, Me; R5 = H, Me, Cl, Br) were produced with primary or secondary alcs. R2(R3)CH2OH as a hydrogen source. Furthermore, the utility of this newly developed protocol is demonstrated through scaled-up experiment, late-stage modification, and preliminary exploration of enantioselective synthesis.
Journal of Organic Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent) (o-amino). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, COA of Formula: C5H12O.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts