ãNi-catalyzed cross-electrophile coupling between vinyl/aryl and alkyl sulfonates: synthesis of cycloalkenes and modification of peptidesã?was written by Duan, Jicheng; Du, Yun-Fei; Pang, Xiaobo; Shu, Xing-Zhong. Computed Properties of C6H15NOThis research focused onvinyl triflate alkyl sulfonate Nickel catalyst reductive cross coupling; peptide alkyl tosylate Nickel catalyst cross coupling. The article conveys some information:
The coupling reactions between vinyl/aryl and alkyl C-O electrophiles that can be derived from chem. feedstocks and naturally occurring functional groups was reported. This method provided an efficient approach to the synthesis of a wide range of functionalized, and/or secondary alkyl substituted cycloalkenes that are difficult to synthesize by conventional methods. The reaction proceeded with broad substrate scope, and tolerated various functional groups such as alc., aldehyde, ketone, ester, amide, alkene, alkyne, heterocycles, organotin and organosilicon compounds The synthetic utility of this method was demonstrated by providing facile access to important building blocks. The possibility to apply this method for late-stage modification of peptides was also demonstrated. A broad range of functionalized alkyl groups was selectively introduced into tyrosine in peptides via C-C bond formation, which was a challenge to the existing procedures. In the part of experimental materials, we found many familiar compounds, such as 6-Aminohexan-1-ol(cas: 4048-33-3Computed Properties of C6H15NO)
6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Computed Properties of C6H15NO
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