Schwartz, Zachary T.; Theisen, Peter D.; Bjornstal, Olaf T.; Rodebaugh, Mary; Jemal, Mauricio A.; Lee, Dallas; Shelton, Spencer D.; Zhao, Zhenze; Du, Liqin; Kerwin, Sean M. published an article in 2022. The article was titled 《Scalable Synthesis and Cancer Cell Cytotoxicity of Rooperol and Analogues》, and you may find the article in Molecules.Formula: C7H6O3 The information in the text is summarized as follows:
Plant polyphenols, such as the African potato (Hypoxis hemerocallidea)-derived bis-catechol rooperol, can display promising anticancer activity yet suffer from rapid metabolism Embarking upon a program to systematically examine potentially more metabolically stable replacements for the catechol rings in rooperol, we report here a general, scalable synthesis of rooperol and analogs that builds on our previous synthetic approach incorporating a key Pd-catalyzed decarboxylative coupling strategy. Using this approach, we have prepared and evaluated the cancer cell cytotoxicity of rooperol and a series of analogs. While none of the analogs examined here were superior to rooperol in preventing the growth of cancer cells, analogs containing phenol or methylenedioxyphenyl replacements for one or both catechol rings were nearly as effective as rooperol. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Formula: C7H6O3)
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Formula: C7H6O3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts