Related Products of 1195-59-1In 2021 ,《Structural and Thermodynamics Studies on Polyaminophosphonate Ligands for Uranyl Decorporation》 appeared in Inorganic Chemistry. The author of the article were Ye, Gaoyang; Roques, Jerome; Solari, Pier-Lorenzo; Den Auwer, Christophe; Jeanson, Aurelie; Brandel, Jeremy; Charbonniere, Loic J.; Wu, Wangsuo; Simoni, Eric. The article conveys some information:
The development of actinide decorporation agents with high complexation affinity, high tissue specificity, and low biol. toxicity is of vital importance for the sustained and healthy development of nuclear energy. After accidental actinide intake, sequestration by chelation therapy to reduce acute damage is considered as the most effective method. Bis- and tetra-phosphonated pyridine ligands were designed, synthesized, and characterized for uranyl (UO22+) decorporation. Owing to the absorption of the ligand and the luminescence of the uranyl ion, UV-visible spectroscopy and time-resolved laser-induced fluorescence spectroscopy (TRLFS) were used to probe in situ complexation and structure variation of the complexes formed by the ligands with uranyl. D. functional theory (DFT) calculations and x-ray absorption fine structure (XAFS) spectroscopy on uranyl-ligand complexes revealed the coordination geometry around the uranyl center at pH 3 and 7.4. High affinity constants (log K ~17) toward the uranyl ion were determined by displacement titration A preliminary in vitro chelation study proves that bis-phosphonated pyridine ligands can remove uranium from calmodulin (CaM) at a low dose and in the short term, which supports further uranyl decorporation applications of these ligands.2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1) was used in this study.
2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Related Products of 1195-59-1
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts