《Direct Synthesis of Deuterium-Labeled O -, S -, N -Vinyl Derivatives from Calcium Carbide》 was written by Ledovskaya, Maria S.; Voronin, Vladimir V.; Rodygin, Konstantin S.; Posvyatenko, Alexandra V.; Egorova, Ksenia S.; Ananikov, Valentine P.. Synthetic Route of C12H20O6 And the article was included in Synthesis on August 31 ,2019. The article conveys some information:
A novel methodol. for the preparation of trideuterovinyl derivatives such as I [R = n-decyl, menthyl, Ph, etc.; X = O, S] and II [R1 = indol-1-yl, NPh2, carbazol-9-yl, etc.] of high purity directly from alcs., thiols, and NH-compounds was developed. Com. available calcium carbide and D2O acted as a D2-acetylene source and DMSO-d6 was used to complete the formation of the D2C=C(D)-X fragment (X = O, S, N). Polymerization of a selected trideuterovinylated compound showed a very promising potential of these substances in the synthesis of labeled polymeric materials. Biol. activity of the synthesized trideuterovinyl derivatives was evaluated and the results indicated a significant increase of cytotoxicity upon deuteration. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Synthetic Route of C12H20O6)
((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-II).Synthetic Route of C12H20O6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts