《Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines》 was published in Nature Communications in 2020. These research results belong to Che, Jiuwei; Niu, Li; Jia, Shikun; Xing, Dong; Hu, Wenhao. Name: (4-Bromophenyl)methanol The article mentions the following:
Here, based on a rhodium/chiral phosphoric acid cooperative catalysis, an enantioselective three-component reaction of α-diazo ketones with alcs. and 1,3,5-triazines was achieved. A dual hydrogen bonding between the chiral phosphoric acid catalyst and two distinct active intermediates was proposed to be crucial for the efficient electrophile-based enantiocontrol. A series of chiral β-amino-α-hydroxy ketones I [R = H, Et, Bn, 1-naphthylmethyl, etc.; R1 = H, Ph, 4-MeC6H4, 4-BrC6H4; R2 = Ph, 4-MeC6H4, 4-BrC6H4; R3 = Ph, 4-MeC6H4, 2-FC6H4, etc.] including those derived from simple aliphatic alcs., allylic alc., propargyl alc., complicated natural alcs. and water could all be prepared in high efficiency and enantioselectivity. After reading the article, we found that the author used (4-Bromophenyl)methanol(cas: 873-75-6Name: (4-Bromophenyl)methanol)
(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Name: (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)
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