《Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study》 was published in Bioorganic Chemistry in 2020. These research results belong to Rahim, Fazal; Zaman, Khalid; Taha, Muhammad; Ullah, Hayat; Ghufran, Mehreen; Wadood, Abdul; Rehman, Wajid; Uddin, Nizam; Shah, Syed Adnan Ali; Sajid, Muhammad; Nawaz, Faisal; Khan, Khalid Mohammed. SDS of cas: 100-83-4 The article mentions the following:
Synthesis and biol. screening of benzimidazole-bearing bis-Schiff bases I (R1 = 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4, 4-BrC6H4; R2 = 3-HOC6H4, 2-O2NC6H4, 2,4-Cl2C6H3, etc.) for their α-glucosidase inhibitory activity are described. All compounds I exhibited excellent to good inhibitory potential (IC50 = 2.20 ± 0.1 to 88.60 ± 1.70μM) when compared with standard drug acarbose (IC50 = 38.45 ± 0.80μM). A structure activity relationship has been established on the basis of electronic effects and position of different substituents present on Ph ring. In order to rationalize the binding interactions of most active analogs with the active site of α-glucosidase enzyme, mol. docking study was conducted. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4
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