Sagha, Mohsen; Mousaei, Fatemeh; Salahi, Mahtab; Razzaghi-Asl, Nima published an article in 2022. The article was titled 《Synthesis of new 2-aminothiazolyl/benzothiazolyl-based 3,4-dihydropyrimidinones and evaluation of their effects on adenocarcinoma gastric cell migration》, and you may find the article in Molecular Diversity.Safety of 3-Hydroxybenzaldehyde The information in the text is summarized as follows:
A number of new 2-aminothiazolyl/benzothiazolyl derivatives of 3,4-dihydropyrimidinones I [R = 4-FC6H4, 4-ClC6H4, 4-O2NC6H4] and II [R1 = Ph, 3-HOC6H4, 3-BrC6H4] were synthesized and structurally identified, and then their effects on the migration behavior of human AGS cells (gastric cancer cells) were investigated. Mol. docking and mol. dynamics (MD) simulations were applied to explore binding potential and realistic binding model of the assessed derivatives through identification of key amino acid residues within L5/α2/α3 allosteric site of kinesin 5 (Eg5) as a validated microtubule-dependent target for monastrol as a privileged DHPM derivative In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde) was used in this study.
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Safety of 3-Hydroxybenzaldehyde
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts