In 2022,Li, Hu; Wu, Zheng-Rong; Chu, Qing-Ru; Liang, Hong-Jie; Liu, Ying-Qian; Wu, Tian-Lin; Ma, Yue published an article in New Journal of Chemistry. The title of the article was 《Potential application value of hydroxychalcones based on isoliquiritigenin in agricultural plant diseases》.Formula: C7H6O3 The author mentioned the following in the article:
To improve the fungicidal activity of the lead compound isoliquiritigenin, 33 hydroxychalcones were designed and prepared Their in vitro antifungal activities against four pathogenic fungi (Rhizoctonia solani, Botrytis cinerea, Fusarium graminearum, and Sclerotinia sclerotiorum) were evaluated systematically. We found the most potent agricultural fungicides to be compounds LH-4, LH-5, LH-14 and LH-15 with EC50 values in the range of 5.96 – 10.06 μg mL-1, which are superior to the lead compound isoliquiritigenin and pos. control azoxystrobin, with compound LH-4 displaying the best in vitro antifungal activity against R. solani with an EC50 value of 5.96 μg mL-1, approx. 6 times more potent than isoliquiritigenin (EC50 = 36.91 μg mL-1). Moreover, the preliminary antifungal mechanism of compound LH-4 illustrated that it could affect the hyphal morphol. and ultrastructure feature of R. solani; its antifungal activity can be associated with the hyphal distortion that results from the disruption of the cell membrane integrity. Besides, SAR studies revealed that the chalcones with few hydroxyls on the A- and B-rings exhibited noticeable antifungal activity. However, chalcones with multi-hydroxyl groups showed unsatisfactory activity. Herein, we report and discuss hydroxychalcones based on isoliquiritigenin as bioactive compounds useful in treating agricultural plant diseases.3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Formula: C7H6O3) was used in this study.
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Formula: C7H6O3
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