Product Details of 7748-36-9In 2022 ,《Palladium-Catalyzed Three-Component Dearomatization/Sulfonylation Cascade》 was published in Organic Letters. The article was written by Bajohr, Jonathan; Bohme, Matthias D.; Gao, Jiacheng; Hahn, F. Ekkehardt; Lautens, Mark. The article contains the following contents:
The diastereoselective synthesis of sulfonylated indolines is reported. A palladium-catalyzed dearomative sulfination of (aza)indole-tethered aryl iodides generates reactive benzylic sulfinates. These intermediates react with electrophiles in a one-pot, two-step process to generate sulfonylated products in good yields and excellent diastereoselectivity. This three-component sequence demonstrates good scalability and can be applied toward the synthesis of sulfonamides. Addnl., further derivatizations of aryl iodide containing products furnish spiro- and alkynylated indoline products. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9
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