Wang, Xiao-Xu; Xu, Yuan-Tai; Zhang, Zhi-Lin; Lu, Xi; Fu, Yao published an article in 2022. The article was titled 《NiH-catalysed proximal-selective hydroalkylation of unactivated alkenes and the ligand effects on regioselectivity》, and you may find the article in Nature Communications.Quality Control of 5-Hexen-1-ol The information in the text is summarized as follows:
Herein, a NiH-catalyzed proximal-selective hydroalkylation of unactivated alkenes e.g., N-(quinoline-8-yl)pent-4-enamide to access β- or γ-branched alkyl carboxylic acids and β-, γ- or δ-branched alkyl amines e.g., 4-methyl-N-(quinolin-8-yl)octanamide was reported. A broad range of alkyl iodides and bromides e.g., 1-iodobutane with different functional groups can be installed with excellent regiocontrol and availability for site-selective late-stage functionalization of biorelevant mols. Under modified reaction conditions with NiCl2(PPh3)2 as the catalyst, migratory hydroalkylation takes place to provide β- (rather than γ-) branched products. The keys to success are the use of aminoquinoline and picolinamide as suitable directing groups and combined exptl. and computational studies of ligand effects on the regioselectivity and detailed reaction mechanisms. The results came from multiple reactions, including the reaction of 5-Hexen-1-ol(cas: 821-41-0Quality Control of 5-Hexen-1-ol)
5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Quality Control of 5-Hexen-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts