In 2022,Kardashliev, Tsvetan; Panke, Sven; Held, Martin published an article in Green Chemistry. The title of the article was 《Efficient synthesis of 2,6-bis(hydroxymethyl)pyridine using whole-cell biocatalysis》.Application In Synthesis of 2,6-Pyridinedimethanol The author mentioned the following in the article:
We demonstrate a novel one-pot biocatalytic process for the preparation of a versatile chem. intermediate, 2,6-bis(hydroxymethyl)pyridine, from naturally-occurring 2,6-lutidine using recombinant microbial whole cells as a catalysts. After scale up, the bioconversion enabled titers exceeding 12 g L-1 with a space-time yield of 0.8 g L-1 h-1. This biocatalytic route offers a simpler and more sustainable alternative to multistep organic synthesis protocols.2,6-Pyridinedimethanol(cas: 1195-59-1Application In Synthesis of 2,6-Pyridinedimethanol) was used in this study.
2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application In Synthesis of 2,6-Pyridinedimethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts