In 2019,Nature Chemistry included an article by Ruffoni, Alessandro; Julia, Fabio; Svejstrup, Thomas D.; McMillan, Alastair J.; Douglas, James J.; Leonori, Daniele. Electric Literature of C3H8ClNO. The article was titled 《Practical and regioselective amination of arenes using alkyl amines》. The information in the text is summarized as follows:
The formation of carbon-nitrogen bonds for the preparation of aromatic amines is among the top five reactions carried out globally for the production of high-value materials, ranging from from bulk chems. to pharmaceuticals and polymers. As a result of this ubiquity and diversity, methods for their preparation impact the full spectrum of chem. syntheses in academia and industry. In general, these mols. are assembled through the stepwise introduction of a reactivity handle in place of an aromatic C-H bond (i.e., a nitro group, halogen or boronic acid) and a subsequent functionalization or cross-coupling. Here we show that aromatic amines can be constructed by direct reaction of arenes and alkyl amines using photocatalysis, without the need for pre-functionalization. The process enables the easy preparation of advanced building blocks, tolerates a broad range of functionalities, and multigram scale can be achieved via a batch-to-flow protocol. The merit of this strategy as a late-stage functionalization platform has been demonstrated by the modification of several drugs, agrochems., peptides, chiral catalysts, polymers and organometallic complexes. The experimental process involved the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Electric Literature of C3H8ClNO)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Electric Literature of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
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