Synthetic Route of C6H15NOIn 2022 ,《A library of Rhodamine6G-based pH-sensitive fluorescent probes with versatile in vivo and in vitro applications》 appeared in RSC Chemical Biology. The author of the article were Swanson, W. Benton; Durdan, Margaret; Eberle, Miranda; Woodbury, Seth; Mauser, Ava; Gregory, Jason; Zhang, Boya; Niemann, David; Herremans, Jacob; Ma, Peter X.; Lahann, Joerg; Weivoda, Megan; Mishina, Yuji; Greineder, Colin F.. The article conveys some information:
Acidic pH is critical to the function of the gastrointestinal system, bone-resorbing osteoclasts, and the endolysosomal compartment of nearly every cell in the body. Non-invasive, real-time fluorescence imaging of acidic microenvironments represents a powerful tool for understanding normal cellular biol., defining mechanisms of disease, and monitoring for therapeutic response. While com. available pH-sensitive fluorescent probes exist, several limitations hinder their widespread use and potential for biol. application. To address this need, we developed a novel library of pH-sensitive probes based on the highly photostable and water-soluble fluorescent mol., Rhodamine 6G. We demonstrate versatility in terms of both pH sensitivity (i.e., pKa) and chem. functionality, allowing conjugation to small mols., proteins, nanoparticles, and regenerative biomaterial scaffold matrixes. Furthermore, we show preserved pH-sensitive fluorescence following a variety of forms of covalent functionalization and demonstrate three potential applications, both in vitro and in vivo, for intracellular and extracellular pH sensing. Finally, we develop a computation approach for predicting the pH sensitivity of R6G derivatives, which could be used to expand our library and generate probes with novel properties. In addition to this study using 6-Aminohexan-1-ol, there are many other studies that have used 6-Aminohexan-1-ol(cas: 4048-33-3Synthetic Route of C6H15NO) was used in this study.
6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Synthetic Route of C6H15NO
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