In 2019,Advanced Synthesis & Catalysis included an article by Oh, Hyunseok; Park, Areum; Jeong, Kyu-Sung; Han, Soo Bong; Lee, Hyuk. COA of Formula: C6H12O. The article was titled 《Copper-Catalyzed 1,2-Bistrifluoromethylation of Terminal Alkenes》. The information in the text is summarized as follows:
The catalytic 1,2-bistrifluoromethylations of alkenes catalyzed by Copper (Cu) have been reported. Two CF3 sources have been used, namely Umemoto’s reagent and (trifluoromethyl)trimethylsilane (TMSCF3). Each reagent plays a unique role during this transformation; Umemoto’s reagent generates CF3 radicals, while TMSCF3 is used to form CF3 anions. Copper (I) bromide (CuBr) exhibited the best catalytic activity for this reaction. CuBr oxidizes the alkyl radical, which is produced by the addition of CF3 radical to the alkenes R(CH2)nCH2=CH2 (Ar = 4-acetamidophenoxy, 3-methylphenoxy, phthalimido, (4-methylbenzene)sulfonamido, 4-formylphenoxy, etc.; n = 1, 2, 3, 4) to the corresponding alkyl cation, which then reacts with the CF3 anion from TMSCF3 to produce the desired products R(CH2)nCH(CF3)CH2CF3. This reaction tolerates a diverse set of substrates bearing functional groups such as amides, esters, ethers, ketones, protected amines, tertiary amines, and phthalimides, hence making this transformation to be widely applicable to a wide variety of substrates. After reading the article, we found that the author used 5-Hexen-1-ol(cas: 821-41-0COA of Formula: C6H12O)
5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.COA of Formula: C6H12O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts