On December 1, 2021, da Silva, Dariane Trivisiol; Smaniotto, Franciele Aline; Costa, Isabella Ferreira; Baranzelli, Julia; Muller, Aline; Somacal, Sabrina; Monteiro, Camila Sant’Anna; Vizzotto, Marcia; Rodrigues, Eliseu; Barcia, Milene Teixeira; Emanuelli, Tatiana published an article.Formula: C8H8O3 The title of the article was Natural deep eutectic solvent (NADES): A strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract. And the article contained the following:
This study investigated whether a ready-to-use extract obtained using a natural deep eutectic solvent (NADES) affects the pharmacokinetic profile of blueberry phenolic compounds compared to organic solvent (SORG)-extracted compounds SORG extract was administered as an aqueous solution after solvent removal. Wistar rats received a single dose of crude extract of blueberry obtained using NADES (CE-NADES) or SORG (CE-SORG), followed by LC-DAD-MS/MS anal. of blood and cecal feces. Non-compartmental pharmacokinetic anal. revealed that CE-NADES increased the bioavailability of anthocyanins by 140% compared to CE-SORG. CE-NADES increased the stability of phenolic compounds during in vitro digestion by delaying gastric chyme neutralization. These results suggest that besides being an eco-friendly solvent for the extraction of phytochems., choline chloride:glycerol:citric acid-based NADES can be used as a ready-to-use vehicle for increasing oral absorption of bioactive compounds such as anthocyanins. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Formula: C8H8O3
The Article related to blueberry phenolic compound bioavailability natural deep eutectic solvent, absorption, anthocyanins, green solvent, intestinal stability, metabolites, pharmacokinetic, Food and Feed Chemistry: Analysis and other aspects.Formula: C8H8O3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts