On June 11, 2015, Kane, John L., Jr.; Matthews, Gloria; Metz, Markus; Kothe, Michael; Liu, Jinyu; Scholte, Andrew published a patent.Category: alcohols-buliding-blocks The title of the patent was Benzimidazole and imidazopyridine derivatives as tropomyosin-related kinase (Trk) inhibitors and their preparation and use for the treatment of diseases. And the patent contained the following:
The invention relates to benzimidazole and imidazopyridine derivatives of formula I, which are tropomyosin-related kinase (Trk) inhibitors and which are useful in the treatment of diseases. Compounds of formula I wherein Q1 is H, halo, (un)substituted C6-14 aryl, etc.; Q2 is (un)substituted C6-14 aryl, (un)substituted C2-9 heteroaryl, etc.; R1 is H, halo, C1-10 alkyl, etc.; R2 is H, halo, C1-10 alkyl, C1-10 alkoxy, etc.; L is (CR3R4)1-5; R3 and R4 are independently H, NH2, C1-10 alkyl, etc.; Z is (CR5R6)0-4; R5 and R6 are independently H, NH2, C1-10 alkyl, etc.; X is CH, halo, NH, etc.; and pharmaceutically acceptable salts thereof, are disclosed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their Trk inhibitory activity. From the assay, it was determined that compound II exhibited IC50 values of 0.001 μM and 0.0005 μM towards TrkA and TrkB, resp. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Category: alcohols-buliding-blocks
The Article related to imidazopyridine preparation trk inhibitor treatment disease, benzimidazole preparation trk inhibitor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Category: alcohols-buliding-blocks
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