On April 8, 2010, Beaulieu, Pierre; Bonneau, Pierre; Coulombe, Rene; Forgione, Pasquale; Gillard, James; Jakalian, Araz; Rancourt, Jean published a patent.Product Details of 386704-04-7 The title of the patent was Dibenzofuran derivatives as viral polymerase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of hepatitis C viral infection. And the patent contained the following:
The application provides compounds of formula I , useful as inhibitors of the hepatitis C virus NS5B polymerase. The application also provides pharmaceutical compositions containing said compounds, methods of using said compounds as pharmaceuticals alone or with other antiviral agent in the treatment of a hepatitis C viral infection in a mammal having or at risk of having the infection. Compounds of formula I wherein either X is absent and Y is O or Y is absent and X is O; n is 0 to 4; R2 is halo, Cn, NO2, SO3H, acyl, amino, etc.; R5 is H, C1-6 alkyl, C3-7 cycloalkyl, C1-6 alkyl-C3-7 cycloalkyl, aryl, etc.; R6 is C3-7 cycloalkyl, C1-6 alkyl-C3-7 cycloalkyl, aryl, etc.; and salts and esters thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their viral polymerase inhibitory activity. From the assay, it was determined that the tested compounds exhibited EC50 values below 40 μM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Product Details of 386704-04-7
The Article related to dibenzofuran preparation viral polymerase inhibitor treatment hepatitis c, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Product Details of 386704-04-7
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