On August 31, 2022, Sakurai, Shuhei; Kawakami, Yuta; Kuroki, Manabu; Gotoh, Hiroaki published an article.Quality Control of 3-Hydroxyphenylacetic acid The title of the article was Structure-antioxidant activity (oxygen radical absorbance capacity) relationships of phenolic compounds. And the article contained the following:
Antioxidant capacity is the extent to which a compound can eliminate reactive oxygen species, and in vitro methods for its chem. evaluation have been proposed. Among these methods, the oxygen radical absorbance capacity (ORAC) assay comes close to the oxidation reaction in the living body because it generates radical species that mimic the lipid peroxyl radical involved in the peroxidation reaction of biol. components and react in a phosphate buffer. In this study, PM7, a semi-empirical MO method, was used to calculate the thermodn. properties (bond dissociation enthalpy, ionisation potential and proton affinity) associated with ORAC. We also applied the clusterwise linear regression anal. as a statistical method for grouping the antioxidants by structure. By analyzing the data for antioxidants, the trend in the hydrophilic ORAC values was determined using the calculated structures and bond dissociation enthalpies of the groups classified according to the presence or absence of oxygen functional groups in the ortho position of phenol. Further studies of indicators other than bond dissociation enthalpy are needed to predict the ORAC of other antioxidants such as flavonoids and indoles. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Quality Control of 3-Hydroxyphenylacetic acid
The Article related to phenolic compound oxygen radical absorbance capacity sar, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Quality Control of 3-Hydroxyphenylacetic acid
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