On January 28, 2021, Kuttruff, Christian Andreas; Bretschneider, Tom; Godbout, Cedrickx; Koolman, Hannes Fiepko; Martyres, Domnic; Roth, Gerald Juergen published a patent.HPLC of Formula: 386704-04-7 The title of the patent was 1-(6-(Methoxy)pyridazin-3-yl)cyclopropane-1-carboxamide derivatives as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases and preparation thereof. And the patent contained the following:
The invention relates to 1-(6-(methoxy)pyridazin-3-yl)cyclopropan-1-carboxamide derivatives of formula I as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases such as e.g. idiopathic lung disease (IFF) or systemic sclerosis (SSc). Compounds of formula I wherein A is substituted pyridyl; E is (un)substituted Ph and (un)substituted pyridyl; K is substituted piperazinyl, substituted piperidinyl, substituted 2,6-diazabicyclo[3.3]heptanyl, etc.; are claimed. N-(4-(7-Acetyl-2,7-diazaspiro[3.5]nonan-2-yl)benzyl)-1-(6-((6-(trifluoromethyl)pyridin-3-yl)methoxy)pyridazin-3-yl)cyclopropane-1-carboxamide (II) was prepared by amidation of 1-(6-((6-(trifluoromethyl)pyridin-3-yl)methoxy)pyridazin-3-yl)cyclopropane-1-carboxylic acid with 1-(2-(4-(aminomethyl)phenyl)-2,7-diazaspiro[3.5]nonan-7-yl)ethan-1-one. The invention compounds were evaluated for their ATX modulatory activity. From the assay, it was determined that compound II exhibited IC50 value of 4.0 nM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).HPLC of Formula: 386704-04-7
The Article related to pyridazinylcyclopropanecarboxamide preparation autotaxin modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.HPLC of Formula: 386704-04-7
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