On December 31, 2020, Wang, Jun; Zhao, Danyue; Tiano, Simoni; Esteban-Fernandez, Adelaida; Yuan, Bo; Smith, Chad; Brathwaite, Justin; Jlayer, Zahra; Wu, Qingli; Simon, James E.; Trageser, Kyle J.; Pasinetti, Giulio M. published an article.Category: alcohols-buliding-blocks The title of the article was Prophylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of social stress. And the article contained the following:
Major depressive disorder (MDD) is a leading cause of disability, and there is an urgent need for new therapeutics. Stress-mediated induction of pro-inflammation in the periphery contributes to depression-like behaviors both in humans and in exptl. models. Inflammatory cytokine interleukin-6 (IL-6) has emerged as a potential therapeutic target. Our studies demonstrated that metabolism of flavanol rich cocoa preparation (FRP) led to the accumulation of select phenolic acids that may contribute to its anti-inflammatory activity. Using a repeated social defeat stress (RSDS) model of depression, we showed that oral administration of FRP attenuates susceptibility to RSDS-mediated depression, supporting the further development of FRP as a novel therapeutic for the treatment of stress disorders and anxiety in humans. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Category: alcohols-buliding-blocks
The Article related to social stress flavanol metabolite resilience prophylaxis, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Category: alcohols-buliding-blocks
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