On October 25, 2010, Uslu, Aylin; Coles, Simon J.; Davies, David B.; Esen, Muekremin; Hursthouse, Michael B.; Kilic, Adem published an article.Reference of 2-Methyl-2-propylpropane-1,3-diol The title of the article was Effect of gem 2,2′-disubstitution and base in the formation of spiro- and ansa-1,3-propandioxy derivatives of cyclotriphosphazenes. And the article contained the following:
The gem-dialkyl effect was studied in the reactions of cyclotriphosphazene, N3P3Cl6 1, with various 2,2′-derivatives of 1,3-propandiol, CXY(CH2OH)2, in either THF or DCM to form spiro (6-membered) and ansa (8-membered ring) derivatives The reactions were made with a number of sym.-substituted (X = Y, Me, Et, Bu and a malonate ester) and unsym.-substituted (X ≠ Y, Me/H, Ph/H, Me/Pr, Et/Bu and Br/NO2) 1,3-propandiols. The products were analyzed by 1H and 31P NMR spectroscopy and some of the spiro and ansa derivatives were also characterized by x-ray crystallog. Reactions of 1 with unsym.-substituted 1,3-propandiols gave two structural isomers of ansa-substituted compounds, both isomers (endo and exo) were structurally-characterized by x-ray crystallog. for the Et/Bu derivative The regioselectivity of the reaction is changed when the base is changed. The relative proportions of spiro and ansa compounds formed under different reaction conditions were quantified by 31P NMR measurements of the reaction mixtures The results were rationalized mainly in terms of the electronic effect of the substituents, whereas the steric effect has a secondary role in the formation of both spiro and ansa compounds The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Reference of 2-Methyl-2-propylpropane-1,3-diol
The Article related to spiro ansa propandioxy cyclotriphosphazene preparation crystal mol structure, cyclocondensation cyclotriphosphazene propandiol gem dialkyl effect, Organometallic and Organometalloidal Compounds: Metal Heterocyclic Compounds and Cluster Compounds and other aspects.Reference of 2-Methyl-2-propylpropane-1,3-diol
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