In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 141699-55-0, formula is C8H15NO3, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Quality Control of 141699-55-0
Yamaki, Susumu;Yamada, Hiroyoshi;Nagashima, Akira;Kondo, Mitsuhiro;Shimada, Yoshiaki;Kadono, Keitaro;Yoshihara, Kosei research published 《 Synthesis and structure activity relationships of carbamimidoylcarbamate derivatives as novel vascular adhesion protein-1 inhibitors》, the research content is summarized as follows. Vascular adhesion protein-1 (VAP-1) is a promising therapeutic target for the treatment of diabetic nephropathy. Here, the authors conducted structural optimization of the glycine amide derivative (I), which the authors previously reported as a novel VAP-1 inhibitor, to improve stability in dog and monkey plasma, and aqueous solubility By chem. modification of the right part in the glycine amide derivative, the authors identified the carbamimidoylcarbamate derivative, which showed stability in dog and monkey plasma while maintaining VAP-1 inhibitory activity. The authors also found that conversion of the pyrimidine ring in the derivative into saturated rings was effective for improving aqueous solubility This led to the identification of two moderate VAP-1 inhibitors with excellent aqueous solubility Further optimization led to the identification of 2-fluoro-3-{3-[(6-methylpyridin-3-yl)oxy]azetidin-1-yl}benzyl carbamimidoylcarbamate (II), which showed similar human VAP-1 inhibitory activity to I with improved aqueous solubility II showed more potent ex vivo efficacy than I, with rat plasma VAP-1 inhibitory activity of 92% at 1 h after oral administration at 0.3 mg/kg. In the pharmacokinetic study, II showed good oral bioavailability in rats, dogs, and monkeys, which may be due to its improved stability in dog and monkey plasma.
Quality Control of 141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.
Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts