Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 141699-55-0, formula is C8H15NO3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Quality Control of 141699-55-0
Ward, John S.;Merritt, Leander;Calligaro, David O.;Bymaster, Franklin P.;Shannon, Harlan E.;Mitch, Charles H.;Whitesitt, Celia;Brunsting, David;Sheardown, Malcolm J.;Olesen, Preben H.;Swedberg, Michael D. B.;Jeppesen, Lone;Sauerberg, Per research published 《 1,2,5-Thiadiazole Analogs of Aceclidine as Potent m1 Muscarinic Agonists》, the research content is summarized as follows. The acetyl group of the muscarinic agonist aceclidine (I) was replaced by various 1,2,5-thiadiazoles to provide a new series of potent m1 muscarinic agonists II. Optimal m1 muscarinic agonist potency was achieved when the 1,2,5-thiadiazole substituent was either a butyloxy or a butylthio group (II; R = OBu, SBu). Although 1,2,5-oxadiazole III and pyrazine IV are iso-π-electronic with 1,2,5-thiadiazole I (R = OBu) both analogs were substantially less active than I (R = OBu). Compounds with high muscarinic affinity and/or m1 muscarinic agonist efficacy were also obtained when the 3-oxyquinuclidine moiety of I (R = OBu, SPr) was replaced by ethanolamines, hydroxypyrrolidines, hydroxyazetidine, hydroxyisotropanes, or hydroxyazanorbornanes. The structure-activity data support the participation of the oxygen or sulfur atom in the substituent on the 1,2,5-thiadiazole in the activation of the m1 receptor. Several of these new 1,2,5-thiadiazoles have m1 agonist efficacy, potency, and selectivity comparable to those of xanomeline (V) in the muscarinic tests investigated.
141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.
Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Quality Control of 141699-55-0
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts