With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 7748-36-9, formula is C3H6O2, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Category: alcohols-buliding-blocks
Toledo-Sherman, Leticia;Breccia, Perla;Cachope, Roger;Bate, Jennifer R.;Angulo-Herrera, Ivan;Wishart, Grant;Matthews, Kim L.;Martin, Sarah L.;Cox, Helen C.;McAllister, George;Penrose, Stephen D.;Vater, Huw;Esmieu, William;Van de Poel, Amanda;Van de Bospoort, Rhea;Strijbosch, Annelieke;Lamers, Marieke;Leonard, Philip;Jarvis, Rebecca E.;Blackaby, Wesley;Barnes, Karen;Eznarriaga, Maria;Dowler, Simon;Smith, Graham D.;Fischer, David F.;Lazari, Ovadia;Yates, Dawn;Rose, Mark;Jang, Sung-Wook;Munoz-Sanjuan, Ignacio;Dominguez, Celia research published 《 Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington’s Disease Models》, the research content is summarized as follows. Genetic and pharmacol. evidence indicates that the reduction of ataxia telangiectasia-mutated (ATM) kinase activity can ameliorate mutant huntingtin (mHTT) toxicity in cellular and animal models of Huntington’s disease (HD), suggesting that selective inhibition of ATM could provide a novel clin. intervention to treat HD. Here, we describe the development and characterization of ATM inhibitor mols. to enable in vivo proof-of-concept studies in HD animal models. Starting from previously reported ATM inhibitors, we aimed with few modifications to increase brain exposure by decreasing P-glycoprotein liability while maintaining potency and selectivity. Here, we report brain-penetrant ATM inhibitors that have robust pharmacodynamic (PD) effects consistent with ATM kinase inhibition in the mouse brain and an understandable pharmacokinetic/PD (PK/PD) relationship. Compound 17 engages ATM kinase and shows robust dose-dependent inhibition of X-ray irradiation-induced KAP1 phosphorylation in the mouse brain. Furthermore, compound 17 protects against mHTT (Q73)-induced cytotoxicity in a cortical-striatal cell model of HD.
7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts