In 2008,Gobbini, Mauro; Armaroli, Silvia; Banfi, Leonardo; Benicchio, Alessandra; Carzana, Giulio; Fedrizzi, Giorgio; Ferrari, Patrizia; Giacalone, Giuseppe; Giubileo, Michele; Marazzi, Giuseppe; Micheletti, Rosella; Moro, Barbara; Pozzi, Marco; Scotti, Piero Enrico; Torri, Marco; Cerri, Alberto published 《Novel Analogues of Istaroxime, a Potent Inhibitor of Na+,K+-ATPase: Synthesis and Structure-Activity Relationship》.Journal of Medicinal Chemistry published the findings.Product Details of 18621-18-6 The information in the text is summarized as follows:
The authors report the synthesis and biol. properties of novel inhibitors of the Na+,K+-ATPase as pos. inotropic compounds Following the previously described model from which istaroxime was generated, the 5α,14α-androstane skeleton was used as a scaffold to study the space around the basic chain of the lead compound Some compounds demonstrated higher potencies than istaroxime on the receptor and the derivative (I) was the most potent; as further confirmation of the model, the E isomers of the oxime are more potent than the Z form. The compounds tested in the guinea pig model induced pos. inotropic effects, which are correlated to the in vitro inhibitory potency on the Na+,K+-ATPase. The finding that all tested compounds resulted less proarrhythmogenic than digoxin, a currently clin. used pos. inotropic agent, suggests that this could be a feature of the 3-aminoalkyloxime derivative class of 5α,14α-androstane. In the part of experimental materials, we found many familiar compounds, such as Azetidin-3-ol hydrochloride(cas: 18621-18-6Product Details of 18621-18-6)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Product Details of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts