Manandhar, Erendra; Johnson, Ashley D. G.; Watson, William M.; Dickerson, Shelby D.; Sahukhal, Gyan S.; Elasri, Mohamed O.; Fronczek, Frank R.; Cragg, Peter J.; Wallace, Karl J. published an article in 2021. The article was titled 《Detection of ferric ions in a gram-positive bacterial cell: Staphylococcus aureus》, and you may find the article in Journal of Coordination Chemistry.Related Products of 1195-59-1 The information in the text is summarized as follows:
A rhodamine-based chemosensor was synthesized and found to selectively bind ferric ions over other metal ions (Na+, K+, Ca2+, Mg2+, Fe2+, Zn2+, Cd2+, Co2+, Hg2+ Cr3+, Al3+) in an organic-aqueous mixture (CH3CN-MES). Upon addition of ferric ions, the spirolactam ring opens, producing a visual color change and a fluorescence intensity increase, i.e. a turn on optical response at 577 nm is observed The chemosensor coordinates to ferric ions in 1:1 stoichiometry with a calculated Ka = 3.5 × 104 mol dm-3 by fluorescence spectroscopy and a LoD of 27 ppb. The chemosensor was reversible upon addition of the Fe3+ chelator desferrioxamine. One- and two-dimensional NMR experiments with Al3+ ions aided in understanding of the coordination environment of the ferric ion with the chemosensor, which were confirmed by mol. modeling calculations X-ray quality crystals of the chemosensor were obtained, and the solid-state structure is reported. Confocal microscopy was used to detect free ferric ions in Staphylococcus aureus. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1)
2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 1195-59-1
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