Chatterjee, Shym S.’s team published research in Chemical Communications (London) in 1968 | CAS: 18621-18-6

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Recommanded Product: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

In 1968,Chatterjee, Shym S.; Triggle, D. J. published 《Synthesis of azetidin-3-ol》.Chemical Communications (London) published the findings.Recommanded Product: 18621-18-6 The information in the text is summarized as follows:

Ph2CHNHCH2CH(OH)CH2Cl, m. 201° (HCl salt), prepared from benzhydrylamine and 1-chloro-2,3-epoxypropane (I), was cyclized to 1-(diphenylmethyl)azetidin-3-ol (II), m. 115°. Hydrogenation of II (as the HCl salt)in EtOH at 60 psi. with 5% Pd-C catalyst gave azetidin-3-ol (III) HCl salt, m. 91-2°. Attempts to prepare III from benzylamine and I failed, since 3-chloro-1-(benzylamino)-2-hydroxypropane could not be cyclized. The experimental part of the paper was very detailed, including the reaction process of Azetidin-3-ol hydrochloride(cas: 18621-18-6Recommanded Product: 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Recommanded Product: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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