《Palladium-Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts》 was written by Che, Yuan-Yuan; Yue, Yanni; Lin, Ling-Zhi; Pei, Bingbing; Deng, Xuezu; Feng, Chao. Application In Synthesis of 3-Pyridinemethanol And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:
Herein, we report a highly efficient and practical method for pyridine-derived heterobiaryl synthesis through palladium-catalyzed electrophilic functionalization of easily available pyridine-derived quaternary phosphonium salts. The nice generality of this reaction was goes beyond arylation, enabling facile incorporation of diverse carbon-based fragments, including alkenyl, alkynyl, and also allyl fragments, onto the pyridine core. Notably, the silver salt additive is revealed to be of vital importance for the success of this transformation and its pivotal role as transmetallation mediator, which guarantees a smooth transfer of pyridyl group to palladium intermediate, is also described. In the experiment, the researchers used 3-Pyridinemethanol(cas: 100-55-0Application In Synthesis of 3-Pyridinemethanol)
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Application In Synthesis of 3-Pyridinemethanol
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