Reference of 5-Hexen-1-olIn 2020 ,《First total synthesis of 5(S)-hydroxyrecifeiolide》 appeared in Synthetic Communications. The author of the article were Kalyankar, Kondbarao Balasaheb; Das, Saibal. The article conveys some information:
The first total synthesis of recently isolated 5(S)-hydroxyrecifeiolide (I) has been described in ten straight forward linear steps with 14% of overall yield. The key reaction involves Jacobsen’s hydrolytic kinetic resolution, Copper catalyzed Grignard reaction, Steglich esterification and ring closing metathesis reaction using Grubbs 2nd generation catalyst making the synthesis very elegant and simple. The stereogenic center at C5 was generated via Jacobsen’s HKR which was confirmed by the Mandelate ester strategy as well as HPLC purity. In addition to this study using 5-Hexen-1-ol, there are many other studies that have used 5-Hexen-1-ol(cas: 821-41-0Reference of 5-Hexen-1-ol) was used in this study.
5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Reference of 5-Hexen-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts