Jaradat, Nidal; Khasati, Ahmad; Hawi, Maram; Hawash, Mohammed; Shekfeh, Suhaib; Qneibi, Mohammad; Eid, Ahmad M.; Arar, Mohammad; Qaoud, Mohammed T. published the artcile< Antidiabetic, antioxidant, and anti-obesity effects of phenylthio-ethyl benzoate derivatives, and molecular docking study regarding α-amylase enzyme>, Safety of 2-(Phenylthio)ethanol, the main research area is phenylthio ethylbenzoate antidiabetic antioxidant antiobesity mol docking alpha amylase.
In addition to their wide therapeutic application, benzoates and benzoic acid derivatives are the most commonly utilized food preservatives. The purpose of this study was to estimate the antioxidant, anti-diabetic, and anti-obesity activities of four 2-(phenylthio)-Et benzoate derivatives utilizing standard biomedical assays. The results revealed that the 2a compound has potent antidiabetic activity through the inhibition of α-amylase and α-glycosidase with IC50 doses of 3.57 ± 1.08 and 10.09 ± 0.70 μg/mL, resp., compared with the pos. control acarbose (IC50 = 6.47 and 44.79 μg/mL), resp. In addition, by utilizing the β-carotene linoleic acid and DPPH methods, the 2a compound showed the highest antioxidant activity compared with pos. controls. Moreover, the 2a compound showed potential anti-lipase activity with an IC50 dose of 107.95 ± 1.88 μg/mL compared to orlistat (IC50 = 25.01 ± 0.78 μg/mL). A mol. docking study was used to understand the interactions between four derivatives of (2-(phenylthio)-Et benzoate with α-amylase binding pocket. The present study concludes that the 2a compound could be exploited for further antidiabetic, antioxidant, and anti-obesity preclin. and clin. tests and design suitable pharmaceutical forms to treat these global health problems.
Scientific Reports published new progress about Antidiabetic agents. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Safety of 2-(Phenylthio)ethanol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts