Wang, Feifei; Kong, Hao; Meng, Xiangfeng; Tian, Xiao; Wang, Changjiang; Xu, Lei; Zhang, Xiang; Wang, Lei; Xie, Ran published the artcile< A light-initiated chemical reporter strategy for spatiotemporal labeling of biomolecules>, Electric Literature of 5505-63-5, the main research area is biomol spatiotemporal labeling light initiated chem reporter strategy.
The emergence of optochem. approaches has had a diverse impact over a broad range of biol. research due to spatiotemporal regulation. Herein, we integrate this feature into the bioorthogonal chem. reporter strategy, which enables visible light-controlled spatiotemporal labeling of cell-surface glycans, lipids, and proteins. The metabolic precursors were first incorporated into live cells, and next the bioorthogonal reaction converted the azide/alkyne into a photo-active functional group, which allowed for subsequent photo-click reaction. We demonstrated this strategy by specifically labeling sialome, mucin-type O-glycome, phospholipids and newly-synthesized membrane proteins, resp. The sequential photoirradiation-orthogonal reporter tagging (SPORT) should facilitate the probing of biomols. in complex biol. systems with high spatiotemporal precision.
RSC Chemical Biology published new progress about Affinity labeling. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Electric Literature of 5505-63-5.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts