Song, Jianxi; Wu, Ye; Ma, Xiaojing; Feng, Lijuan; Wang, Zhiguo; Jiang, Guiquan; Tong, Haibin published the artcile< Structural characterization and α-glycosidase inhibitory activity of a novel polysaccharide fraction from Aconitum coreanum>, Application of C6H12O6, the main research area is Aconitum polysaccharide ACPP1 structure glycosidase inhibitor; A. coreanum polysaccharides (ACPP); Characterization; α-Glycosidase.
α-Glycosidase is an essential target for the management of postprandial serum glucose in diabetic patients. Therefore, the interest has been growing in the screening of α-glycosidase inhibitor from natural resource. In the present study, the structure and α-glycosidase inhibitory activity of a polysaccharide (named as ACPP-1) from Aconitum coreanum were investigated. Based on the results from high performance gel permeation chromatog., GC-MS and 1D/2D NMR spectroscopy, ACPP-1 was a highly-linear polysaccharide with a mol. weight of 34.0 kD and containing over 90% of glucose. It was composed of (1→4)-α-D-Glcp and α-Araf. ACPP-1 exhibited a dose-dependent inhibitory effect against α-glycosidase activity in vitro and the IC50 value was ∼0.8 mg/mL. In oral starch tolerance test, treatment with ACPP-1 (800 mg/kg) significantly improved the starch tolerance in mice. Taken together, this study provided a potential intervention and management for postprandial hyperglycemia by the polysaccharide fraction from A. coreanum.
Carbohydrate Polymers published new progress about Aconitum coreanum. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application of C6H12O6.
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