Divakaran, Anand et al. published their research in ACS Medicinal Chemistry Letters in 2022 | CAS: 499-75-2

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C10H14O

Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader was written by Divakaran, Anand;Scholtz, Cole R.;Zahid, Huda;Lin, Wenwei;Griffith, Elizabeth C.;Lee, Richard E.;Chen, Taosheng;Harki, Daniel A.;Pomerantz, William C. K.. And the article was included in ACS Medicinal Chemistry Letters in 2022.Synthetic Route of C10H14O This article mentions the following:

Targeted protein degradation is a powerful induced-proximity tool to control cellular protein concentrations using small mols. However, the design of selective degraders remains empirical. Among bromodomain and extra-terminal (BET) family proteins, BRD4 is the primary therapeutic target over family members BRD2/3/T. Existing strategies for selective BRD4 degradation use pan-BET inhibitors optimized for BRD4:E3 ubiquitin ligase (E3) ternary complex formation, but these result in residual inhibition of undegraded BET-bromodomains by the pan-BET ligand, obscuring BRD4-degradation phenotypes. Using our selective inhibitor of the first BRD4 bromodomain, iBRD4-BD1 (I) (IC50 = 12 nM, 23- to 6200-fold intra-BET selectivity), we developed dBRD4-BD1 to selectively degrade BRD4 (DC50 = 280 nM). Notably, dBRD4-BD1 upregulates BRD2/3, a result not observed with degraders using pan-BET ligands. Designing BRD4 selectivity up front enables anal. of BRD4 biol. without wider BET-inhibition and simplifies designing BRD4-selective heterobifunctional mols., such as degraders with new E3 recruiting ligands or for addnl. probes beyond degraders. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Synthetic Route of C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts