Enantioselective radical C-H amination for the synthesis of β-amino alcohols was written by Nakafuku, Kohki M.;Zhang, Zuxiao;Wappes, Ethan A.;Stateman, Leah M.;Chen, Andrew D.;Nagib, David A.. And the article was included in Nature Chemistry.Reference of 2968-93-6 This article mentions the following:
Asym., radical C-H functionalizations are rare but powerful tools for solving modern synthetic challenges. Specifically, the enantio- and regioselective C-H amination of alcs. to access medicinally valuable chiral β-amino alcs. remains elusive. To solve this challenge, a radical relay chaperone strategy was designed, wherein an alc. was transiently converted to an imidate radical that underwent intramol. H-atom transfer (HAT). This regioselective HAT was also rendered enantioselective by harnessing energy transfer catalysis to mediate selective radical generation and interception by a chiral copper catalyst. The successful development of this multi-catalytic, asym., radical C-H amination enabled broad access to chiral β-amino alcs. from a variety of alcs. containing alkyl, allyl, benzyl and propargyl C-H bonds. Mechanistic experiments revealed that triplet energy sensitization of a Cu-bound radical precursor facilitates catalyst-mediated HAT stereoselectivity, enabling the synthesis of several important classes of chiral β-amines by enantioselective, radical C-H amination. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Reference of 2968-93-6).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 2968-93-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts