Hybrid Organo- and Biocatalytic Process for the Asymmetric Transformation of Alcohols into Amines in Aqueous Medium was written by Liardo, Elisa;Rios-Lombardia, Nicolas;Moris, Francisco;Rebolledo, Francisca;Gonzalez-Sabin, Javier. And the article was included in ACS Catalysis in 2017.Recommanded Product: tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate This article mentions the following:
A hybrid organo- and biocatalytic system for the asym. conversion of racemic alcs. into amines was developed. Combining an organocatalyst, AZADO, an oxidant, NaOCl, and an enzyme, ω-transaminase, implemented a one-pot oxidation-transamination sequential process in aqueous medium. The method showed broad substrate scope and was successfully applied to conventional secondary alcs. and sterically hindered β-substituted cycloalkanols, where a highly stereoselective dynamic asym. bioamination enabled us to set up both contiguous stereocenters with very high enantio- and diastereomeric ratio (>90% yield, >99% ee, and up to 49:1 dr). In the experiment, the researchers used many compounds, for example, tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate (cas: 155975-19-2Recommanded Product: tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate).
tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate (cas: 155975-19-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts