Ni-Catalyzed Reductive 1,2-Cross-Dialkylation of Unactivated Alkenes with Two Alkyl Bromides was written by Zhang, Jian-Xin;Shu, Wei. And the article was included in Organic Letters in 2022.Synthetic Route of C10H20O This article mentions the following:
Herein, a Ni-catalyzed reductive 1,2-dialkylation of unactivated aliphatic alkenes had been developed using two different alkyl bromides to gave (cyanoethyl)-alkyl-aryl-propanamides R1CH2CHR2CH2C(O)NHAr [R1 = cyanomethyl, H2CCO2Et, (2-oxotetrahydrofuran-3-yl); R2 = Et, n-Pr, 3-phenylpropyl, etc.; Ar = Ph, 4-MeC6H4, 3-MeOC6H4, etc.]. The reaction proceeded smoothly under mild conditions to install two Csp3-Csp3 bonds onto directed aliphatic alkenes, demonstrating excellent chemo- and regioselectivity with good functional group tolerance. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Synthetic Route of C10H20O).
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Synthetic Route of C10H20O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts